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var tabPanel = new Ext.TabPanel({
    items: [...],
    listeners: {
        beforeremove: function (container, component) {
            if (!component.allowRemove) {
                Ext.MessageBox.confirm('Confirm Action', 'Message', function (btn) {
                    if (btn == 'yes') {
                        component.allowRemove = true;
                        container.remove(component);
                    }
                },
                this);
                return false;
            }
        }
    }
});

через Conditionally Close Tab, How ?? – Ext JS Forums.

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